Abstract:

Objective To investigate the effect of multimodal analgesia based on regional block on postop⁃ erative rehabilitation in liver cancer patients with undergoing laparotomy. Methods From June 2019 to May 2020， 80 patients undergoing laparotomy for liver cancer in our hospital were selected. The patients were randomly divid⁃ ed into regional block group（group R）and control group（group C）. The time of awakening and the digital analog pain score（NRS score），the dosage of analgesics and the incidence of postoperative nausea and vomiting（PONV） were compared between the two groups at the moment of awakening，24 h and 48 h after operation. The changes of plasma TNF ⁃α，IL ⁃6 and liver function index，QoR ⁃15 score of postoperative recovery quality and postoperative hospital stay were recorded. Results The time of awakening in group R was significantly shorter than that in group C（P＞0.01），and the NRS score immediately after awakening and within 24 h after operation in group R was sig⁃ nificantly lower than that in group C（all P＜0.05）. The use of postoperative analgesics in group R was significant⁃ ly lower than that in group C，and the incidence of PONV at 24 h after operation in group R was significantly lower than that in group C（P＜0.05）. The levels of TNF⁃an and IL⁃6 at T1 and T2 in group R were significantly lower than those in group C（P＜0.05）. The levels of ALT，TBIL and ALB in group R were lower than those in group C， and the QoR⁃15 score was higher than that in group C. the postoperative hospital stay in group R was shorter than that in group C（P＜0.05）. Conclusion The multimode analgesia scheme of general anesthesia combined with re⁃ gional block could improve the analgesic effect，reduce adverse reactions，effectively inhibit inflammatory factors， improve early analgesic effect of patients with liver cancer after laparotomy，and reduce hospital stay，which is wor⁃ thy of clinical application.

Key words:

general anesthesia, regional block, multimodal analgesia, liver cancer, postoperative rehabilitation